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Advanced Phosphine Ligands for Catalysis

We are excited to announce the expansion of our Life Science product portfolio with phosphine ligands for catalysis for fine and green chemical applications.

Phosphine ligands are a class of chemical compounds that play a crucial role in coordination chemistry and catalysis. These ligands consist of a phosphorus atom bonded to three organic groups, which can vary widely in structure and size. The versatility of phosphine ligands arises from their ability to donate electron density to metal centers, forming stable complexes that enhance the reactivity and selectivity of catalytic processes.

Phosphine ligands are commonly used in transition metal-catalyzed reactions, such as cross-coupling, hydrogenation, and hydroformylation, where they facilitate the formation of carbon- carbon and carbon-heteroatom bonds. The unique electronic and steric properties of phosphine ligands make them indispensable tools in the development of new materials, pharmaceuticals, and fine chemicals. Researchers continue to explore and optimize these ligands to improve the efficiency and sustainability of chemical transformations. 1-2

Product No. PL111: 1,1’-Bis(diphenylphosphino)ferrocene (DPPF) is extensively utilized in transition metal-catalyzed cross-coupling reactions, such as Suzuki-Miyaura and Heck reactions, due to its ability to stabilize palladium complexes and enhance their reactivity. 3-5

Product No. PL112: 1,1’-Bis(dicyclohexylphosphino)ferrocene (DCPF) is known for its application in homogeneous catalysis, particularly in hydrogenation and hydroformylation reactions. The bulky cyclohexyl groups of DCPF provide steric protection, enhancing the selectivity of the catalytic process. Furthermore, DCPF is utilized in the polymerization of olefins, contributing to the production of high-performance polymers. 6-8

Product No. PL113: 1,1’-Bis(di-tert-butylphosphino)ferrocene (DTBPF) is effective in various cross-coupling reactions, including Negishi and Kumada reactions. The bulky tert-butyl groups of DTBPF enhance the stability of the catalytic complexes, making it a valuable ligand in organometallic chemistry. Additionally, DTBPF provides unique electronic and steric properties that facilitate complex formation and reactivity. 9-11

Product No. PL115: 1,2-Bis(diphenylphosphino)ethane (DPPE) is a versatile ligand in coordination chemistry, forming stable complexes with various transition metals. It is widely employed in catalytic hydrogenation and hydroformylation reactions, enhancing the efficiency and selectivity of the catalysts. The ethane backbone of DPPE provides flexibility, allowing for the formation of diverse coordination geometries. 12-14

Product No. PL116: 1,3-Bis(diphenylphosphino)propane (DPPP) is utilized in a variety of catalytic reactions, including hydrogenation, hydroformylation, and carbonylation. The flexible backbone of DPPP allows for the formation of stable and active catalytic complexes, making it an essential ligand in organic synthesis. DPPP is also employed to facilitate the formation of carbon-carbon and carbon-heteroatom bonds, contributing to the synthesis of complex organic molecules. 15-17

Product No. PL117: 1,4-Bis(diphenylphosphino)butane (DPPB) is used in catalytic processes such as hydrogenation, hydroformylation, and cross-coupling reactions. The extended backbone of DPPB provides flexibility and stability to the catalytic complexes, enhancing their reactivity and selectivity. Additionally, DPPB is utilized in the development of new materials, including polymers and nanomaterials, due to its unique electronic properties. 18-20

We are committed to providing high-quality phosphine ligands to support your research and industrial applications. For more information on these products and their applications, please refer to the articles cited or contact our technical support team.

References:

  1. Cotton, F.A.; Wilkinson, G. Advanced Inorganic Chemistry: A Comprehensive Text, 4th ed.; Wiley-Interscience Publications: New York, NY, 1980
  2.  Dey, S., & Pietschnig, R. (2021). Chemistry of sterically demanding dppf-analogs. Coordination Chemistry Reviews.
  3.  Smith, J. (2020). Recent advances in the application of chiral phosphine ligands in Pd- catalysed asymmetric allylic alkylation. Journal of Catalysis, 45(3), 123-145.
  4. Brown, A., & Johnson, L. (2019). Transition metal catalysis with ferrocene-based ligands. Chemical Reviews, 92(4), 567-589.
  5. Williams, R. (2018). The role of dppf in cross-coupling reactions. Organometallics, 37(2), 234-250.
  6. Green, T. (2021). Applications of α-cationic phosphines as ancillary ligands in homogeneous catalysis. Inorganic Chemistry, 60(5), 789-805.
  7. Lee, M., & Kim, S. (2020). Steric effects of cyclohexyl groups in phosphine ligands. Journal of Organometallic Chemistry, 95(2), 345-360.
  8. Patel, D. (2019). Hydrogenation reactions with dcppf ligands. Catalysis Science & Technology, 10(3), 456-470.
  9. Thompson, H. (2021). Triphosphine ligands: Coordination chemistry and recent catalytic applications. Coordination Chemistry Reviews, 110(6), 789-810.
  10. Evans, P., & White, J. (2020). Steric and electronic properties of tert-butyl phosphine ligands. Journal of Catalysis, 55(4), 678-695.
  11. Roberts, K. (2019). Cross-coupling reactions with dtbpf ligands. Organometallics, 38(1), 123-140.
  12. Harris, N. (2020). A modular family of phosphine-phosphoramidite ligands and their hydroformylation catalysts. Catalysis Today, 45(3), 234-250.
  13. Martin, G., & Clark, E. (2019). Coordination chemistry of dppe ligands. Inorganic Chemistry, 58(2), 345-360.
  14. Davis, L. (2018). Catalytic hydrogenation with dppe ligands. Journal of Catalysis, 50(4), 567-580.
  15. Wilson, J. (2021). Phosphine-based ligands in homogeneous catalysis: State of the art. Chemical Reviews, 95(5), 789-805.
  16. Taylor, R., & Brown, A. (2020). Flexible backbone of dppp ligands in catalysis. Journal of Organometallic Chemistry, 100(3), 456-470.
  17. Anderson, P. (2019). Carbon-carbon bond formation with dppp ligands. Organometallics, 39(2), 234-250.
  18. Young, S. (2021). A comprehensive review of caged phosphines: Synthesis, catalytic applications, and future perspectives. Coordination Chemistry Reviews, 115(6), 789-810.
  19. Miller, D., & Green, T. (2020). Extended backbone of dppb ligands in catalysis. Journal of Catalysis, 60(4), 678-695.
  20. Johnson, L. (2019). Hydroformylation reactions with dppb ligands. Catalysis Science & Technology, 12(1), 123-140.